Status:
COMPLETED
Biological Determinants of Sputum Rheology in Chronic Airway Diseases
Lead Sponsor:
University Hospital, Montpellier
Collaborating Sponsors:
APARD Fonds de dotation
Conditions:
Asthma
COPD
Eligibility:
All Genders
18+ years
Brief Summary
The primary objective of this study is to investigate the biological determinants of sputum rheology variations.
Detailed Description
Secondarily, this study aims to compare rheology parameters between different chronic airway disease sub-populations.
Eligibility Criteria
Inclusion
- Affiliate with or beneficiary of the French national single-payer health insurance system
- Patient capable of spontaneous mucus expectoration
- Consulting or hospitalized at the study centre
- Inclusion Criteria for the Asthma Group
- Never- or former-smoker (\<10 pack-years)
- Medical history compatible with asthma
- Reversible post-brochodilator (or post-corticosteroid test) ventilatory obstruction (ratio of forced expiratory volume in 1 second : forced vital capacity \< 70%) or significant variation in respiratory function -- OR -- Bronchial hyperresponsiveness demonstrated during a broncho-provocation test
- Inclusion Criteria for the COPD Group
- Current- or former-smokers (\>10 pack years)
- Chronic obstructive pulmonary disease according to GOLD criteria
- Inclusion Criteria for the Bronchiectasis Group
- Presence of bronchiectasis on computed tomography scan
- Cystic fibrosis has been ruled out
Exclusion
- Patient expresses opposition to the protocol
- Breast feeding or pregnant
- Metastatic neoplastic disease
- Other active pulmonary disease (tuberculosis, interstitial lung disease)
- Recent psychiatric disorder (in the past year and documented via a specialist consult)
- Consumption of illicit drugs or alcoholism
- Patients in an exclusion period determined by another study
- Patients under any type of legal guardianship
- Prisoners
- Impossible to correctly inform the patient
- Does not fluently read French
- Emergency situations
Key Trial Info
Start Date :
September 15 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 15 2019
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT04081740
Start Date
September 15 2019
End Date
October 15 2019
Last Update
November 7 2019
Active Locations (1)
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1
Arnaud de Villeneuve Hospital
Montpellier, France, 34295