Status:
COMPLETED
Relative Oral Bioavailability of GABA From Tomatoes
Lead Sponsor:
Wageningen University
Collaborating Sponsors:
Nunhems
Agrico Research
Conditions:
GABA Plasmakinetics
Eligibility:
MALE
18-28 years
Phase:
NA
Brief Summary
In this four-way crossover study, a plasmakinetic profile of GABA from tomatoes as compared to a gamma-aminobutyric acid (GABA) supplement in healthy young men will be established. In addition, a plas...
Eligibility Criteria
Inclusion
- BMI between 18.5 and 25 kg/m2
- Age is between 18 and 28 years
- Good general health
- Male
- Veins suitable for blood sampling
- Able to speak Dutch
Exclusion
- Is currently suffering from a disease including mental disorders
- Has had any gastrointestinal condition/disease within the 3 months prior to the intervention
- Haemoglobin (Hb) level \< 8.5 mmol/L
- Has used medication in the two months before and/or during the intervention. Occasional use of NSAIDs or paracetamol (\<once a week on average) are is allowed.
- Reported weight loss or weight gain of \> 2 kg in the month prior to the intervention
- Use of dietary supplements, 3 weeks before-, or during the intervention.
- Allergic to products that are provided as part of the standardised diet
- Unwilling to consume the products that are part of the standardised diet
- Allergic to tomatoes
- (History of) drug abuse, in this case meaning \>1 x per month use of recreational drugs
- Smoking
- Alcohol consumption of \>10 standardised glasses per week.
- Not able to refrain from alcohol consumption 2 days before each test day
- Recent or planned blood donation (\<3 month prior to first study day or during intervention)
- Personnel of Wageningen University, department of Human Nutrition and Health,
- Currently participating in other research or was participating in another study within 1 month of the intervention or within 3 months if invasive procedures were used.
Key Trial Info
Start Date :
November 4 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 5 2019
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT04086108
Start Date
November 4 2019
End Date
December 5 2019
Last Update
January 21 2020
Active Locations (1)
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1
Wageningen University, Division of Human Nutrition
Wageningen, Netherlands