Status:
SUSPENDED
Restoring Molecular Circadian Rhythm
Lead Sponsor:
University of Pennsylvania
Conditions:
Healthy Young
Healthy Elderly
Eligibility:
All Genders
20-85 years
Brief Summary
The goal is to address the mechanisms that account for alteration of circadian rhythms with age. As the blood of aged individuals can produce this alteration, the investigators propose to use such blo...
Eligibility Criteria
Inclusion
- General good health with the following conditions permissible
- cardiovascular risk prevention, intake of low dose aspirin,
- hypertension, intake of beta-blockers, ACE inhibitors, diuretics, calcium channel blockers
- hypercholesterinemia, intake of statins
- Cases: 70-85 years of age
- Controls: 20-35 years of age
- Patients must be able to read and understand English
- Participants must sign the informed consent form
- Participants must have a wrist-actigraphy-based average TST (total sleep time) ≥ 6 hours per night (measured over 7 consecutive days) occurring between 22:00 - 08:00
Exclusion
- Known history of severe psychiatric or cognitive conditions, for example mania, schizophrenia, or mental retardation
- Shift work, defined as recurring work between 22:00-05:00
- History of clinically significant obstructive sleep apnea
- Transmeridian travel across ≥2 time zones in the two weeks prior to the blood draws and one week after,
- \> 2 drinks of alcohol per day
- Use of illicit drugs
Key Trial Info
Start Date :
August 19 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2028
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04086589
Start Date
August 19 2019
End Date
December 1 2028
Last Update
January 24 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania, United States, 19104