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Status:

COMPLETED

Mechanical Thrombectomy in Acute Ischemic Stroke Beyond the Time of Window

Lead Sponsor:

Assiut University

Collaborating Sponsors:

Ain Shams University

Aswan University Hospital

Conditions:

Acute Ischemic Stroke

Eligibility:

All Genders

18-80 years

Phase:

NA

Brief Summary

Background: intravenous alteplase appears to be much less effective at opening proximal occlusions of the major intracranial arteries, which account for more than one third of cases of acute anterior-...

Detailed Description

Background Expanding time window using the emerging technologies for mechanical thrombectomy can improve chances of achieving successful thrombectomy and improve clinical outcome in patients that woul...

Eligibility Criteria

Inclusion

  • Inclusion criteria
  • Patients Aged between 18 and 80 years old.
  • Patients with acute ischemic stroke due to occlusion of the MCA or ICA suitable for endovascular treatment, as evidenced by CTA, MRA or angiogram.
  • 4\. Patients with symptoms onset between 6- 24 hours from arrival to the time of femoral puncture.
  • Exclusion criteria
  • A. Clinical exclusion criteria:
  • Patients known to have hemorrhagic diathesis, coagulation factor deficiency, or oral anticoagulant therapy with INR \> 2.0.
  • Patients with a pre-existing neurological or psychiatric disease that would confound the neurological evaluations; mRS score before the onset of stroke must be ≤ 1.
  • B. Neuroimaging exclusion criteria:
  • Patients with hypodensity on CT accounting to an ASPECTS score of \<7.
  • Patients with CT or MRI evidence of hemorrhage (the presence of micro-bleeds is allowed).
  • Patients Significant mass effect with midline shift on CT brain.
  • Subjects with occlusions in multiple vascular territories (e.g., bilateral anterior circulation, or anterior/posterior circulation) on CT brain.

Exclusion

    Key Trial Info

    Start Date :

    January 15 2019

    Trial Type :

    INTERVENTIONAL

    Allocation :

    ACTUAL

    End Date :

    October 20 2019

    Estimated Enrollment :

    57 Patients enrolled

    Trial Details

    Trial ID

    NCT04087382

    Start Date

    January 15 2019

    End Date

    October 20 2019

    Last Update

    September 9 2020

    Active Locations (2)

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    Page 1 of 1 (2 locations)

    1

    Ahmed El-Bassiony

    Cairo, Cairo, Egypt, Egypt

    2

    Abdalla Khalil

    Aswān, Select State/Province, Egypt, 11577