Status:
COMPLETED
Insulin Resistance in Adolescents
Lead Sponsor:
University of Wisconsin, Madison
Collaborating Sponsors:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions:
Insulin Resistance
Eligibility:
All Genders
12-18 years
Phase:
NA
Brief Summary
The growing population of adolescents with insulin resistance (IR) is predicted to create a large public health burden in the next few decades. This study examines the function of brain blood vessels ...
Detailed Description
One in five American adolescents is obese. Up to half of those are already exhibiting insulin resistance (IR), a hallmark of metabolic syndrome and diabetes linked to serious life-altering health diso...
Eligibility Criteria
Inclusion
- Age 12-18 years inclusive
- Typically developing and cognitively intact
Exclusion
- Diabetes (≥126 mg dL-1 fasting glucose)
- Insulin treatment or sensitizing drugs
- Diagnosis of kidney, pulmonary, or heart disease
- Current smoking (defined as use of nicotine \>5 times in the past month)
- Pregnancy
- Neurological or developmental disorders (e.g., intellectual disability, autism)
- Significant head injury or medical conditions (e.g., concussion, encephalopathy, seizure disorder)
- Inability to undergo the MRI procedure
- Weight less than 94.5 lbs (42.9 kg) to adhere to safety guidelines regarding blood sampling and OGTT administration
- Tanner Stage \<3
- Any other circumstance deemed by the PI not addressed above
Key Trial Info
Start Date :
October 4 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 31 2022
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT04089332
Start Date
October 4 2019
End Date
July 31 2022
Last Update
September 5 2024
Active Locations (1)
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1
University of Wisconsin-Madison
Madison, Wisconsin, United States, 53706