Status:
ACTIVE_NOT_RECRUITING
The Role of microRNA-210 in Regulating Oxidative Stress in Patients With PAD
Lead Sponsor:
University of West Florida
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Peripheral Arterial Disease
Vascular Diseases, Peripheral
Eligibility:
All Genders
30+ years
Phase:
NA
Brief Summary
MicroRNA-210 (miR-210) can be a potential therapeutic target of patients with peripheral artery disease (PAD). Recent evidence suggests the role of miR-210 and oxidative stress in the pathophysiology ...
Detailed Description
The investigators will randomize 180 PAD patients that undergoing a revascularization operation in two groups: (1) an endovascular procedure or (2) an open bypass procedure. They are also planning to ...
Eligibility Criteria
Inclusion
- male or female 30 years or older,
- Infrainguinal PAD,
- critical limb ischemia, defined as arterial insufficiency with gangrene, nonhealing ischemic ulcer, or rest pain consistent,
- candidate for both endovascular and open infra-inguinal revascularization as judged by the vascular surgeons,
- absence of musculoskeletal (most commonly arthritis related) or neurologic (most commonly back pain and sciatica related) symptoms,
- willingness to comply with protocol, attend follow-up appointments, complete all study assessments, and provide written informed consent.
Exclusion
- life expectancy of less than 2 years due to reasons other than PAD,
- acute lower extremity ischemic event secondary to thromboembolic disease or acute trauma,
- current chemotherapy or radiation therapy
Key Trial Info
Start Date :
September 15 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 25 2025
Estimated Enrollment :
230 Patients enrolled
Trial Details
Trial ID
NCT04089943
Start Date
September 15 2019
End Date
August 25 2025
Last Update
January 10 2025
Active Locations (2)
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1
UT Austing Dell Medical School
Austin, Texas, United States, 78712
2
Baylor Scott and White
Temple, Texas, United States, 76508