Status:
UNKNOWN
Clinical and Biochemical Assessment of the Effect of Topical Use of Coenzyme Q10 Versus Topical Corticosteroid in Management of Symptomatic Oral Lichen Planus: Randomized Controlled Clinical Trial
Lead Sponsor:
Cairo University
Conditions:
Oral Lichen Planus
Eligibility:
All Genders
15-70 years
Phase:
PHASE1
Brief Summary
The aim of the present investigation is to assess the clinical therapeutic effect of topical use of Coenzyme Q10 versus topical corticosteroid in management of symptomatic oral lichen planus and deter...
Detailed Description
Oral lichen planus (OLP) is a relatively common chronic inflammatory mucocutaneous autoimmune disease that primarily affects the skin and mucosal surfaces including the oral cavity with a variety of c...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Patients free from any systemic disease according to the detailed questionnaire of the modified Cornell Medical Index 34.
- Patients not receiving any medication either topical or systemic that could cause lichenoid reaction during the 3 months before the study.
- Patients diagnosed by a dermatologist and oral medicine specialist as suffering from OLP.
- Patients clinically and histopathologically diagnosed as suffering from OLP according to World Health Organization's (WHO's) clinic-pathological diagnostic criteria for LP35.
- Patients who agree for the biopsy in undiagnosed cases.
- Patients who are willing to participate in this study (will give informed consent) and have the ability to complete the study.
- Exclusion criteria:
- (1) Patients taking systemic drugs such as systemic steroid, other immunosuppressive therapy for at least 8 weeks prior to the study.
- (2) Patients treated with any oral topical medications for at least four weeks prior to the study.
- (3) Patients with suspected restoration-related reaction. (4) Pregnant and lactating mothers.
Exclusion
Key Trial Info
Start Date :
October 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2021
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT04091698
Start Date
October 1 2019
End Date
November 1 2021
Last Update
September 17 2019
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