Status:
COMPLETED
The Acute Effect of Propionate on Energy Homeostasis
Lead Sponsor:
Imperial College London
Conditions:
Obesity
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The research project aims to examine the effect of a dietary supplement called propionate on how the human body in healthy adults aged (18- 65 years) responds to during fasting, exercise and following...
Detailed Description
Dietary fibres have long been recognised for their important role in a healthy diet due to their negative association with, and even management of, chronic diseases such as obesity, diabetes, metaboli...
Eligibility Criteria
Inclusion
- Healthy volunteers (body mass index (BMI) of 18-35 kg/m2)
- Age between 18-65 years (inclusive)
Exclusion
- Weight change of ≥ 3kg in the preceding 2 months
- Current smokers
- Substance abuse
- Excess alcohol intake
- Pregnancy
- Diabetes
- Cardiovascular disease
- Cancer
- Gastrointestinal disease e.g. inflammatory bowel disease or irritable bowel syndrome
- Kidney disease
- Liver disease
- Pancreatitis
- Started new medication within the last 3 months likely to interfere with energy metabolism, appetite regulation and hormonal balance, including: anti-inflammatory drugs or steroids, antibiotics, androgens, phenytoin, erythromycin or thyroid hormones.
- Involved in current research or have recently been involved in any research prior to recruitment in the past 12 weeks.
Key Trial Info
Start Date :
February 12 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 7 2019
Estimated Enrollment :
53 Patients enrolled
Trial Details
Trial ID
NCT04093453
Start Date
February 12 2018
End Date
August 7 2019
Last Update
August 23 2024
Active Locations (1)
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1
Imperial Clinical Research Facility
London, United Kingdom, W12 0HS