Status:
COMPLETED
Tissue Sodium in Patients With Psoriasis
Lead Sponsor:
Charite University, Berlin, Germany
Collaborating Sponsors:
German Heart Center
Conditions:
Psoriasis Vulgaris
Healthy
Eligibility:
All Genders
18-80 years
Brief Summary
Sodium can be buffered in the skin, which mechanism is altered during aging and in certain diseases such as hypertension. High salt environment can promote autoimmunity by expanding pathogenic IL-17 p...
Detailed Description
The cytokine interleukin-17A (IL-17A) is a crucial player in the pathogenesis of the autoimmune disease of psoriasis. This neutrophil recruiting cytokine is produced by IL-17A producing CD4+ T cells (...
Eligibility Criteria
Inclusion
- Age: 18-80
- Body mass index (BMI) 18.5- 40 kg/m2
- Glomerular filtration rate \>60 ml/min/1.73m2
Exclusion
- Diagnosed or treated hypertension and/or blood pressure above 140/90 at screening
- Palpable peripheral oedema during phyisical examination at screening
- Any type of diabetes mellitus and/or HgbA1c\>6.5% at screening
- Subjects with a thyroid-stimulating hormone \>4.2 mU/L at screening
- Psoriasis patients treated with systemic corticosteroids, chemotherapy agent (methothrexate) or with any kind of biologics/biosimilars
- Subjects with acute disease
- Pregnant or lactating women
- Metal or medical device implant in the body
- Tattoo on the lower extremities
- Subjects with a history of drug or alcohol abuse
- Subjects who are legal incapacitated or their circumstances do not enable the patient to fully understand the nature, significance and scope of this study.
Key Trial Info
Start Date :
July 1 2015
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 17 2019
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT04095130
Start Date
July 1 2015
End Date
September 17 2019
Last Update
September 19 2019
Active Locations (1)
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1
Experimental and Clinical Research Center, Clinical Research Unit
Berlin, Germany, 13125