Status:
COMPLETED
Multidisciplinary Translational Approach to Investigate Mechanisms Predictors & Prevention of Persistent PTH
Lead Sponsor:
Mayo Clinic
Collaborating Sponsors:
University of Arizona
Translational Genomics Research Institute
Conditions:
Post-Traumatic Headache
Eligibility:
All Genders
18-70 years
Phase:
PHASE2
Brief Summary
This is a United States Department of Defense funded Focused Program study that aims to identify mechanisms and predictors for persistent of post-traumatic headache attributed to mild traumatic brain ...
Detailed Description
The human studies component of this Focused Program includes clinical phenotyping, neurophysiology, molecular and genetic biomarker discovery, brain imaging, and a clinical trial.These data will be ut...
Eligibility Criteria
Inclusion
- Have a diagnosis of acute PTH attributed to mild traumatic injury to the head as defined by the International Classification of Headache Disorders (ICHD-3).
- PTH onset 7-56 days prior to the time of enrollment
- Adults 18-70 years of age
- Willing to be randomized to either of the two clinical trial treatment arms
- Willing to maintain a headache diary
- Willing and able to return for follow-up visits
- 4 or more moderate or severe headache days during the 4-week run-in phase and an increase of at least 2 moderate to severe headache days compared to pre-TBI and at least a 30% increase
- At least 80% compliant with diary keeping during the 4-week run-in phase (i.e., provides data on at least 80% of days)
Exclusion
- Chronic headache (i.e., at least 15 headache days/month for more than 3 months) within 12 months prior to the mTBI that led to the current PTH, including PPTH, chronic migraine, medication overuse headache, new daily persistent headache, hemicrania continua, chronic tension-type headache
- Diminished decision-making capacity that in the investigator's opinion would interfere with the person's ability to provide informed consent and complete study procedures
- Started or changed dose of a headache preventive medication within the 3 months prior to screening
- Use of onabotulinumtoxinA in the head, neck or face region within 6 months of screening
- During the 6 months before screening, use of opioids or barbiturates on an average of at least 4 days per month
- Subjects who underwent an intervention or used a device (e.g., nerve blocks, transcranial magnetic stimulation, vagal nerve stimulation, or electrical trigeminal nerve stimulation) for headache within 3 months of screening
- History of major psychiatric disorder such as schizophrenia and bipolar disorder
- History or evidence of any unstable or clinically significant medical condition, that in the opinion of the investigator, would pose a risk to subject safety or interfere with the study evaluation, procedures, or completion
- History of positive neuroimaging findings that indicate a moderate or severe TBI
- Contraindications to magnetic resonance imaging, including, but not limited to (only an exclusion for patients participating in the brain MRI portion of this research):
- Metal implants
- Aneurysm clips
- Severe claustrophobia
- Implanted electronic device
- Insulin or infusion pump
- Cochlear/otologic/ear implant
- Non-removable prosthesis
- Implanted shunts/catheters
- Certain intrauterine devices
- Tattooed makeup
- Body piercings that cannot be removed
- Metal fragments
- Wire sutures or metal staples
- Factors that reduce MR image quality and interpretability (only an exclusion for patients participating in the brain MRI portion of this research):
- Dental braces or other non-removable devices (e.g., retainers)
- Prior brain surgery
- Known brain MRI abnormality that in the investigator's opinion will significantly impact MRI data
- Sensory disorders that in the investigator's opinion might affect perception of cutaneous thermal stimuli (e.g., peripheral neuropathy) (only an exclusion for patients participating in the neurophysiology studies)
- Pregnancy
- Breastfeeding
- History of myocardial infarction, stroke, transient ischemic attack, unstable angina, coronary artery bypass surgery, or other revascularization procedures within 12 months prior to screening.
- Not willing to use a reliable form of contraception (for women of childbearing potential) through 16 weeks after the last dose of erenumab. Acceptable methods of birth control include not having intercourse, hormonal birth control methods, intrauterine devices, surgical contraceptive methods, or two barrier methods (each partner must use a barrier method) with spermicide. A reliable form of contraception must be started prior to or at the time of starting the run-in phase. Not being of childbearing potential is defined as any woman who is post-menopausal by history, defined as:
- At least 55 years of age with cessation of menses for 12 or more months; OR
- Younger than 55 years of age but no spontaneous menses for at least 2 years; OR
- Younger than 55 years of age and spontaneous menses within the past 1 year, but currently amenorrheic (e.g., spontaneous or secondary to hysterectomy), AND with postmenopausal gonadotropin levels (luteinizing hormone and follicle-stimulating hormone levels at least 40 IU/L) or postmenopausal estradiol level (less than 5 ng/dL) or according to the definition of "postmenopausal range" for the laboratory involved; OR
- Underwent bilateral oophorectomy; OR
- Underwent hysterectomy; OR
- Underwent bilateral salpingectomy.
- Currently or within 90 days prior to screening: received treatment in another drug study or an investigational device study
- Has previously received any CGRP ligand or receptor targeted monoclonal antibody
Key Trial Info
Start Date :
January 4 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 10 2024
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT04098250
Start Date
January 4 2021
End Date
January 10 2024
Last Update
October 23 2025
Active Locations (5)
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1
Phoenix VA Health Care System
Phoenix, Arizona, United States, 85012
2
Mayo Clinic
Phoenix, Arizona, United States, 85054
3
Mayo Clinic in Arizona
Scottsdale, Arizona, United States, 85259
4
Mayo Clinic
Jacksonville, Florida, United States, 32224