Status:
COMPLETED
Multiple Breath Washout (MBW) Using Sulfur Hexafluoride Reference Values and Influence of Anthropometric Parameters
Lead Sponsor:
Universitätsmedizin Mannheim
Conditions:
Healthy Subjects
Smokers
Eligibility:
All Genders
18+ years
Brief Summary
Multiple breath washout (MBW) using Sulphur hexafluoride (SF6) has the potential to reveal ventilation heterogeneity in obstructive lung disease which is frequent in patients with small airway disease...
Eligibility Criteria
Inclusion
- non-smoker
- no history of pulmonary disease
- absence of dyspnoea, cough, thoracic pain
- no self-reported smoking history
- normal lung function testing
- normal shape of flow-volume curve
- normal shape of flow-pressure curve
- FEV1/FVC \>70% (forced expiratory volume in 1 second / forced vital capacity)
- TLC \> 80% of predicted (total lung capacity)
- TLCO/VA \> 80% of predicted (transfer factor corrected for ventilated alveolar volume)
- R5 \< 150% of predicted (resistance at 5Hz, impulse oscillometry)
- smoker
- \- as above, but with self-reported smoking history \>10 pack years
Exclusion
- unwilling or unable to give informed consent
- history of any respiratory disease
Key Trial Info
Start Date :
August 1 2015
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2019
Estimated Enrollment :
104 Patients enrolled
Trial Details
Trial ID
NCT04099225
Start Date
August 1 2015
End Date
May 1 2019
Last Update
September 23 2019
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