Status:
COMPLETED
Luminex-based Assay to Identify Major IgE-binding Episode Among IgE-mediated Wheat-allergic Patient
Lead Sponsor:
Mahidol University
Collaborating Sponsors:
Icahn School of Medicine at Mount Sinai
Samitivej Hospital group
Conditions:
Wheat Allergy
Eligibility:
All Genders
1-18 years
Brief Summary
This study will be using Luminex-based peptide assay (LPA) to determine major IgE-binding epitope among wheat allergic children to differentiate clinical phenotype.
Detailed Description
Luminex-based peptide assay (LPA) is a novel tool using machine learning techniques, developed to predict different degrees of food allergy has been successfully reported among cow's milk protein alle...
Eligibility Criteria
Inclusion
- Inclusion criteria
- Patients with IgE-mediated wheat allergy, with one of the following criteria; 1.1 a convincing clinical history of the reactions within 4 hours after wheat ingestion during the past 12 months combined with positive skin prick test (SPT) and/or the level of specific IgE (sIgE) to wheat or 1.2 a positive oral food challenge (OFC) result to wheat during the past 12 months OR
- Patients with wheat tolerant confirmed by negative oral food challenge (OFC) result to wheat during the past 12 months OR
- Patients with IgE-mediated wheat allergy and underwent wheat oral immunotherapy for at least 6 months or at the maintenance phase of the treatment
- Exclusion criteria Patients with delayed allergic reactions after wheat ingestion greater than 4 hours
Exclusion
Key Trial Info
Start Date :
September 13 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2022
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04100122
Start Date
September 13 2019
End Date
December 31 2022
Last Update
May 6 2023
Active Locations (1)
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1
Siriraj Hospital
Bangkoknoi, Bangkok, Thailand, 10700