Status:
UNKNOWN
The Effect of the GM-CSF Gel on the Endometrial Thickness in Infertile Women With Thin Endometrium
Lead Sponsor:
Sir Run Run Shaw Hospital
Conditions:
Thin Endometrium
Eligibility:
FEMALE
18-40 years
Phase:
NA
Brief Summary
The purpose of this study is to investigate the efficacy of the granulocyte-macrophage colony stimulating factor(GM-CSF) gel on the endometrial thickness in infertile women with thin endometrium.
Detailed Description
The thin endometrium is detrimental to embryo implantation, probability of clinical pregnancy for an endometrial thickness ≤ 7 mm was significantly lower compared with cases with endometrial thickness...
Eligibility Criteria
Inclusion
- Woman undergoes IVF treatment, 18-40 years old
- The endometrial thickness \<7mm on the day of human chorionic gonadotropin during IVF or after taking oral estradiol valerate 6mg/d for 14 days.
- Embryo transfer is cancelled because of thin endometrium
- No intrauterine adhesion according to the 3-D ultrasonography
Exclusion
- Systemic diseases unable to conceive
- Chromasome abnormal
- History of G-CSF or GM-CSF allergy or untoward effect
- Thin endometrium related to clomid
- Severe or moderate uterine adhesion
- The influence factor of embryo implantation: hydrosalpinx, endometriosis, adenomyosis,myoma of uterus
- Uterine malformation, adenomyosis, uterine leiomyoma sized more than 2cm.
- Patients who is allergic to granulocyte-macrophage colony stimulating factor
- Patients with inflammation of reproductive organs, pelvic cavity inflammation, malignant tumor of reproductive organs and other systemic diseases that could cause metrorrhagia
Key Trial Info
Start Date :
October 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2020
Estimated Enrollment :
96 Patients enrolled
Trial Details
Trial ID
NCT04100655
Start Date
October 1 2019
End Date
December 1 2020
Last Update
September 24 2019
Active Locations (1)
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1
Sir Run Run Shaw Hospital
Hangzhou, Zhejiang, China, 310018