Status:
COMPLETED
Alternative Substrates in the Critically Ill Subject
Lead Sponsor:
Barts & The London NHS Trust
Collaborating Sponsors:
Bristol Royal Infirmary
Institute of Child Health
Conditions:
Critical Illness
Eligibility:
All Genders
18-99 years
Phase:
NA
Brief Summary
The over-arching aim of this study is to investigate the feasibility of administrating alternative substrates to intensive care unit (ICU) patients. This includes reconstituting and administering a mo...
Detailed Description
Aggressive muscle wasting occurs early in critical illness, and is associated with a greater number of days on a ventilator, increased length of intensive care unit (ICU) and/or hospital stay, and sub...
Eligibility Criteria
Inclusion
- 18 years or older
- due to receive enteral nutrition via nasogastric or nasojejunal tube as part of routine care
- mechanically ventilated and likely to remain so for \>48 hours
- likely to remain on the ICU for \>5 days
- likely to survive for at least 10 days and
- multi-organ failure (Sequential Organ Failure Assessment Score \[SOFA\] score \>2 in 2 or more domains).
Exclusion
- primary neuromyopathy or significant neurological impairment at the time of ICU admission that would preclude physical activity
- uni- or bilateral lower limb amputation
- requiring sole or supplemental parenteral nutrition
- need for specialist nutritional intervention
- patients with known inborn errors of metabolism
- participation in another clinical trial
Key Trial Info
Start Date :
October 2 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 27 2022
Estimated Enrollment :
29 Patients enrolled
Trial Details
Trial ID
NCT04101071
Start Date
October 2 2019
End Date
April 27 2022
Last Update
August 1 2022
Active Locations (2)
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1
Bristol Royal Infirmary
Bristol, United Kingdom, BS2 8HW
2
Royal London Hospital
London, United Kingdom, E1 1BB