Status:
COMPLETED
Genistein Stimulates Insulin Sensitivity Through Gut Microbiota
Lead Sponsor:
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Collaborating Sponsors:
National Council of Science and Technology, Mexico
Conditions:
Metabolic Syndrome
Obesity
Eligibility:
All Genders
20-60 years
Phase:
NA
Brief Summary
There is evidence that genistein present in soy can improve insulin resistance in rodents and humans with metabolic syndrome (MetS). However, it is not known if this improvement is associated with cha...
Detailed Description
The investigators included 45 participants who met the following inclusion criteria: adults between 20 and 60 years of age with a diagnosis of MetS, HOMA index greater than 2.5, BMI ≥30 and ≤ 40 kg / ...
Eligibility Criteria
Inclusion
- Adults (men and women) between the ages of 18 and 50.
- Patients with obesity (BMI ≥ 30 and ≤ 40 kg / m2) and with insulin resistance (HOMA - IR Index ≥ 2.5).
- Mexican mestizos (parents and grandparents born in Mexico).
- Patients who can read and write.
Exclusion
- • Patients with any type of diabetes.
- Patients with kidney disease diagnosed by a medical or with creatinine\> 1.3 mg / dL for men and \> 1.1 mg / dL for women and / or BUN\> 20 mg / dL.
- Patients with acquired diseases that produce obesity and diabetes secondarily.
- Patients who have suffered a cardiovascular event.
- Patients with weight loss \> 3 kg in the last 3 months.
- Patients with any catabolic diseases.
- Gravidity status
- Positive smoking
- Treatment with any medication
Key Trial Info
Start Date :
September 15 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2018
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT04105023
Start Date
September 15 2013
End Date
December 1 2018
Last Update
September 26 2019
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