Status:
COMPLETED
Prevalence, Impact and Reversibility of Acute Diaprhagmatic Dysfunction in Acute Respiratory Detresse
Lead Sponsor:
Centre Hospitalier Universitaire de Nice
Conditions:
Respiratory Distress Syndrome,Adult
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The diaphragm is a fine striated muscle with both extra respiratory and respiratory functions. It does most of the breathing work in interaction with the accessory respiratory muscles, the rib cage an...
Eligibility Criteria
Inclusion
- Hospitalization for acute respiratory distress management
- Etiological diagnosis either:
- Exacerbation of chronic obstructive pulmonary disease
- Infectious pneumonitis
- Acute pulmonary edema
- Need for a ventilatory support by either:
- Non-invasive ventilation
- High flow oxygen therapy (flow rate \> 40L/min and oxygen inspired fraction \> 40%)
- Mask oxygen therapy with flow rate \> 5L/min
Exclusion
- Exacerbation of interstitial pathology / pulmonary fibrosis
- Deformation of the thoracic cage
- Neurodegenerative pathology
- Need for oro-tracheal intubation from the beginning for mechanical ventilation
- Contraindication to Non-invasive Ventilation
- Patients undergoing diaphragmatic rehabilitation
- Immunocompromised patients
- History of known diaphragmatic dysfunction
Key Trial Info
Start Date :
April 5 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 5 2022
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT04106128
Start Date
April 5 2019
End Date
October 5 2022
Last Update
November 18 2023
Active Locations (1)
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1
CHU de Nice
Nice, France, 06003