Status:
WITHDRAWN
The Influence of Ventilation on Perioperative Neurocognitive Disorders
Lead Sponsor:
Université Libre de Bruxelles
Conditions:
Cognitive Dysfunction
Eligibility:
All Genders
65-85 years
Phase:
NA
Brief Summary
This prospective study is designed to examine the influence of intra-operative ventilation on perioperative neurocognitive disorders in patients undergoing total hip arthroplasty.
Detailed Description
Perioperative neurocognitive disorders (PND's) remain an important complication after surgery. After many years of speculating about the etiology of this complication, currently studies are pointing t...
Eligibility Criteria
Inclusion
- Patients with an ASA (American Society of Anesthesia) score of I- III
- Scheduled for total hip arthroplasty
Exclusion
- lack of local language comprehension
- neuropsychiatric disturbance
- history of drug/alcohol abuse
- use of anticholinergic drugs, benzodiazepines, opiates/neuroleptic drugs
- patients with an infectious disease within the last month/immune-suppressant therapy within the last 2 months (e.g., azathioprine or cyclosporine) or chronic medication with potential immune-modulatory effects
- patients who underwent major surgery within the last 3 months
- Patients with cardiovascular, or respiratory diseases (including smoking) resulting in clinically relevant impaired function
- Patients with pre-existing CVA, dementia, and other neurological conditions that would interfere with their ability to participate cognitively
- patients with active malignancy
Key Trial Info
Start Date :
November 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2022
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04106869
Start Date
November 1 2019
End Date
March 1 2022
Last Update
May 10 2023
Active Locations (1)
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1
CHU-Charleroi Hopital Civil Marie Curie
Charleroi, Hainaut, Belgium