Status:
UNKNOWN
Dynamic Connectivity Under Metabolic Constraints
Lead Sponsor:
Stony Brook University
Collaborating Sponsors:
Martinos Center for Biomedical Imaging
Conditions:
Insulin Resistance
Healthy
Eligibility:
All Genders
18-79 years
Phase:
PHASE4
Brief Summary
The investigators are studying the impact of insulin resistance on the acceleration of brain aging and testing whether increased neuron insulin resistance can be counteracted by utilization of alterna...
Eligibility Criteria
Inclusion
Exclusion
- claustrophobia
- history of neurological disease, heart attack, stroke, kidney disease, or myxedema
- chronic usage of alcohol
- current usage of psychotropic medication
- Type 1 diabetes mellitus
- Regular consumption of insulin, Metformin® or other medications (statins, NSAIDs, beta-blockers, glucocorticoids) that affect glucose and/or insulin utilization.
- difficulty swallowing
- pregnancy
- breastfeeding
- For PET: research imaging-related radiation exposure that exceeds current MGH Radiology Radiation Safety Commitee guidelines.
- Inclusion Criteria:
- BMI \< 30
- MRI compatible
- For PET with Optional 150 ml Blood Sampling Only: Must weigh at least 110 lbs to minimize risks per PHRC guidelines.
- 20/20 vision or correctable to 20/20 with contact lenses
Key Trial Info
Start Date :
June 19 2015
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2022
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04106882
Start Date
June 19 2015
End Date
September 1 2022
Last Update
September 27 2019
Active Locations (2)
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1
Martinos Center for Biomedical Research, Building 149
Charlestown, Massachusetts, United States, 02129
2
Bioengineering Building , Stony Brook University
Stony Brook, New York, United States, 11794