Status:
COMPLETED
Prospective Comparisons of Clinical Trial and Real-world Outcomes in Nasopharyngeal Carcinoma
Lead Sponsor:
Sun Yat-sen University
Conditions:
Nasopharyngeal Carcinoma
Eligibility:
All Genders
8-79 years
Brief Summary
Study results from randomized controlled trials (RCTs) usually have been found not adequately inform practice. A RCT is optimized to determine efficacy, while real-world study is conducted in a routin...
Detailed Description
Study results from randomized controlled trials (RCTs) usually have been found not adequately inform practice. A RCT is optimized to determine efficacy. Such trials were performed with relatively smal...
Eligibility Criteria
Inclusion
- Patients treated in our center from April 2009 to December 2016;
- All patients were pathologically diagnosed, non-metastatic nasopharyngeal carcinoma;
- Only included cases staged as T3-4N1 \& T1-4N2-3 according to the 6th or 7th edition American Joint Committee on Cancer / Union for International Cancer Control (AJCC/UICC) system;
- For trial patients, treatment strategies only limited to concurrent chemoradiotherapy, induction chemotherapy combined with concurrent chemoradiotherapy, or concurrent chemoradiotherapy combined with adjuvant chemotherapy;
- For patients from real-world database, patients are permitted to receive additional targeted therapy to standard chemoradiotherapy, as far as it met clinical needs and was approved by physicians.
- The patient's basic information, prognosis related data, and follow-up data are complete.
Exclusion
- The clinical stage of T3-4N0 was excluded;
- Cases from large real-world databases need to exclude patients who participate in clinical trials;
Key Trial Info
Start Date :
June 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2019
Estimated Enrollment :
5448 Patients enrolled
Trial Details
Trial ID
NCT04108338
Start Date
June 1 2019
End Date
August 1 2019
Last Update
October 1 2019
Active Locations (1)
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1
Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, China, 510060