Status:
RECRUITING
Effects of Aerobic Exercise Intensity on Clinical & Neural Outcomes in Depressed Youth
Lead Sponsor:
The Royal's Institute of Mental Health Research
Conditions:
Depression
Eligibility:
All Genders
16-24 years
Phase:
NA
Brief Summary
This study will assess the effects of moderate vs. high intensity aerobic exercise, performed 3 times a week for 12 weeks under supervised conditions, on symptoms of depression, cognitive functioning ...
Detailed Description
Rationale: Major depressive disorder (MDD) is a debilitating disorder characterized by persistent negative mood and a broad range of cognitive, and functional impairments. MDD is estimated to affect 4...
Eligibility Criteria
Inclusion
- Currently experiencing depression (MDD or PDD);
- Free of pharmacotherapy (ie. antidepressant medication) for \>5 weeks;
- Not currently engaging in regular moderate or vigorous intensity exercise;
- Able to read/understand English;
- Body mass index \[BMI\] \< 40;
- Medically cleared to engage in aerobic exercise.
Exclusion
- Currently engaged in another exercise trial;
- Another Axis I/II DSM-5 disorder, apart from co-morbid anxiety disorder(s);
- Current or lifetime history of serious medical or neurological conditions;
- Currently taking psychoactive drugs (occasional use of anti-anxiety medication permitted);
- Regular user of nicotine products;
- Unstable medical conditions, especially those that prevent exercise;
- Exhibiting significant suicide risk;
- MRI contraindications;
- Currently pregnant or breastfeeding.
Key Trial Info
Start Date :
August 7 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04110041
Start Date
August 7 2018
End Date
September 1 2025
Last Update
April 12 2024
Active Locations (1)
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1
University of Ottawa Institute of Mental Health Research
Ottawa, Ontario, Canada, K1Z 7K4