Status:
COMPLETED
Sodium Lactate Infusion in GLUT1DS Patients
Lead Sponsor:
Radboud University Medical Center
Conditions:
GLUT1 Deficiency Syndrome
GLUT1DS1
Eligibility:
All Genders
6-18 years
Phase:
EARLY_PHASE1
Brief Summary
This study investigates the effect of lactate infusion on epileptic discharges on EEG and seizure frequency in glucose transporter 1 deficiency syndrome (GLUT1DS) patients.
Detailed Description
In glucose transporter 1 deficiency syndrome (GLUT1DS) cerebral glucose uptake from the systemic blood circulation is limited, because of deficient transport of glucose across the blood-brain barrier ...
Eligibility Criteria
Inclusion
- Diagnosed with GLUT1DS and known in our center.
- Baseline characteristics include a high frequency of clinical seizures and epileptic discharges on EEG.
- History of trying ketogenic diet with good compliance without beneficial effects.
- Age \> 6 years.
- Informed consent.
Exclusion
- Additional medical condition or illness that impairs the patient's ability to participate in the study (for example actual treatment of a malignancy, active infection, poorly controlled diabetes mellitus, hypertension, organ failure, clinically significant haematological or biochemical abnormalities).
- Elevated serum sodium (\> 145 mmol/L).
- Participation in another interventional study at start of the study or during the study.
- Presence of known panic disorders or a history of panic attacks.
Key Trial Info
Start Date :
May 20 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 18 2022
Estimated Enrollment :
2 Patients enrolled
Trial Details
Trial ID
NCT04112862
Start Date
May 20 2022
End Date
November 18 2022
Last Update
November 23 2022
Active Locations (1)
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1
Radboudumc
Nijmegen, Gelderland, Netherlands, 6500GA