Status:
COMPLETED
Effect of L-arginine on Microcirculation, Myogenesis and Angiogenesis Associated With Aging, Sarcopenia and Diabetes
Lead Sponsor:
Rio de Janeiro State University
Collaborating Sponsors:
Laboratory for Clinical and Experimental Research on Vascular Biology
Conditions:
Aging
Sarcopenia
Eligibility:
FEMALE
20-85 years
Phase:
NA
Brief Summary
This study aims was evaluated the effect of L-arginine on microcirculation, vasoreactivity / endothelial function and vascular smooth muscle of young and old women with Sarcopenia or Type 2 Diabetes M...
Detailed Description
Aging causes responsible endothelial changes, in part by a decrease in the blood flow of the skeletal muscles of the elderly. Reduction of muscle mass / function (Sarcopenia) and Diabetes Mellitus are...
Eligibility Criteria
Inclusion
- young women aged between 20 - 30 years, IMC \< 24.9 kg/m2
- older women over 65 years healthy, BMI \<35 kg/m2.
- Elderly women with or without a preexisting diagnosis of diabetes mellitus with fasting plasma glucose (FPG) \> 100 mg/dL were classified into type 2 diabetes mellitus.
Exclusion
- involved type 1 diabetes mellitus
- insulin use, cognitive impairment
- frailty
- disorders cardiometabolic
- liver and/or kidney dysfunction
- autoimmune diseases
- smoking
- rigorous exercise
- uncontrolled hypertension with pressure level \> 140/90 mmHg, with up to two antihypertensive drugs of different classes.
Key Trial Info
Start Date :
April 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2019
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT04112875
Start Date
April 1 2016
End Date
September 1 2019
Last Update
October 2 2019
Active Locations (1)
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1
State University of Rio de Janeiro
Rio de Janeiro, Brazil, 20550900