Status:
COMPLETED
Microwave Needle Thermoablation for Treatment of Localized Prostate Cancer
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Prostate Cancer
Eligibility:
MALE
45-75 years
Phase:
NA
Brief Summary
Conventional treatment options for localized prostate cancer include prostatectomy, radiotherapy and active surveillance. However, prostatectomy and radiotherapy carry certain degree of morbidity, inc...
Detailed Description
Prostate cancer screening with Prostate specific antigen (PSA) has resulted in an increase in the diagnosis of localized prostate cancer. The traditional approach for treating low-risk and intermediat...
Eligibility Criteria
Inclusion
- Men aged between 45 - 75 years
- Life expectancy \> 10 years upon recruitment
- Localized low or intermediate risk prostate cancer diagnosed on MRI-Ultrasound fusion targeted biopsy
- Organ-confined prostate cancer on MRI
- PSA \< 20 ng/mL
- At least 1 MRI visible lesion present and size ≤15mm, and Targeted biopsy showing Gleason score 6 (with cancer core length ≥6mm) or Gleason score 7 (3+4 or 4+3), With or without positive Systematic biopsy (out of 24 systematic cores) away from MRI visible target showing Gleason 6 cancer
Exclusion
- Patients unfit for MRI exam or MR gadolinium contrast
- Patients with previous treatment of prostate cancer
- Patients with maximal length of target lesion \>15mm
- Patients with MRI-visible or invisible lesion within 10mm from rectum or 10mm from sphincter on MRI
- Patients with \>3 areas (MRI-visible or invisible) of prostate cancer
- Patients with Gleason score 4+4 or any Gleason pattern 5 cancer
- Patients with bladder pathology including bladder stone and bladder cancer
- Patients with urethral stricture
- Patients with neurogenic bladder and/or sphincter abnormalities
Key Trial Info
Start Date :
October 8 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 11 2023
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04113811
Start Date
October 8 2019
End Date
April 11 2023
Last Update
May 7 2025
Active Locations (1)
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1
Prince of Wales Hospital, Chinese University of Hong Kong
Hong Kong, Hong Kong