Status:
COMPLETED
Fluid Overload Quantification in Septic Shock
Lead Sponsor:
Centre Hospitalier Universitaire de Besancon
Collaborating Sponsors:
Don du Souffle de Besançon
Hopital Lariboisière
Conditions:
Intensive Care Units
Shock, Septic
Eligibility:
All Genders
18-80 years
Brief Summary
Fluid management in septic shock patients remain a great challenge. Insufficient fluid filling lead to hypovolemia, organ failure and increased death, whereas fluid overload was associated to an incre...
Detailed Description
Patients suffering from septic shock admitted in our critical care unit for less than 24 hours will be eligible. TBW, ECW and ICW volumes will be measured using the BCM just before (T0), just at the e...
Eligibility Criteria
Inclusion
- Patient aged from 18 to 80 years old
- Admitted to ICU for septic shock for less than 24 h
- Fluid resuscitation decided by intensivist
- Patient affiliated to a social security system or recipient of a such system
- Patient/proxy not opposed to the study
Exclusion
- Subject with amputation of 1 or more limbs
- Body mass index \> 35 kg.m-2 ou \< 18 kg.m-2
- Impossibility of setting up an arterial catheter for invasive blood pressure monitoring and / or a central venous catheter in the upper cava territory
- Patient with pacemaker and / or implantable cardioverter defibrillator
- Quality of cardio echo image insufficient to allow studied parameters measurement
- Moribund subject ( life expectancy expected less than 48 hours)
- Uncontrolled intracranial hypertension (intracranial pressure ≥ 20 mm Hg by ICP monitoring or by a pulsatility index ≥ 1.30 in the transcranial Doppler)
- Patient under ECMO/ECLS
- Legal incapacity or limited legal capacity
- Subject without health insurance
- Pregnant woman
- Subject being in the exclusion period of another study or provided for by the "National Volunteer File"
Key Trial Info
Start Date :
January 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2023
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT04114162
Start Date
January 1 2020
End Date
December 31 2023
Last Update
April 23 2025
Active Locations (1)
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1
Centre Hospitalier Universitaire de Besançon
Besançon, France, 25030