Status:
COMPLETED
A Relation of Morphine-induced Itch and Pain Processing
Lead Sponsor:
Aalborg University
Conditions:
Morphine
Itch
Eligibility:
All Genders
20-65 years
Phase:
NA
Brief Summary
In This experiment, the investigators would like to test the two following hypotheses regarding the mechanisms by which opioids cause itch: 1. Opioids cause itch by a spinal disinhibition mechanism (...
Detailed Description
Intrathecal and orally administered opioids are heavily used for the treatment of several acute pain conditions. However, while opioids are effective analgesics for acute pain, they are well-known to ...
Eligibility Criteria
Inclusion
- Healthy men and women in the age of 20-65 years
- The participants must be able to speak and understand English
Exclusion
- Participants with any clinically significant abnormalities that in the opinion of the investigator may increase the risk associated with trial participation or may interfere with the interpretation of the trial results.
- Pregnant or lactating female persons
- Drug addiction defined as the use of cannabis, opioids or other drugs
- Previous or present neurologic, musculoskeletal or mental illnesses
- Current pain and itch causing diseases or psychiatric disorders
- Participants unable to understand or follow the instructions
- Participating in another study where investigational drug is used
- Participants had known allergy/discomfort to morphine
- Lack of ability to cooperate
Key Trial Info
Start Date :
January 15 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 7 2020
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT04115462
Start Date
January 15 2020
End Date
July 7 2020
Last Update
July 8 2020
Active Locations (1)
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1
Mech-Sense, Medicinsk Gastroenterologisk ambulatorium, Medicineshus, Aalborg Universitetshospitalet,
Aalborg, North Denmark, Denmark, 9000