Status:
COMPLETED
The Effect of Different States of Lipid in Food on Glycaemia, Lipaemia and Insulinaemia.
Lead Sponsor:
Singapore Institute of Food and Biotechnology Innovation
Conditions:
Diabetes Mellitus, Type 2
Cardiovascular Risk Factor
Eligibility:
MALE
21-40 years
Phase:
NA
Brief Summary
The aim of this study is to investigate if the application of lipid in various form (i.e. liquid and solid) affects glycaemia, lipaemia and insulinaemia. In addition, this study aims to test the lipid...
Detailed Description
The study will have a randomized, non-blinded, crossover design. This study will explicitly compare the effects of different forms of fat (liquid and solid) on glucose, insulin and lipid response on 2...
Eligibility Criteria
Inclusion
- Males
- Healthy Asian Chinese
- Aged between 21 - 40 years
- ≥45kg body weight
- Body mass index between 18.5 to 25.0 kg/m2
- Normal blood pressure ≤140/90 mmHg
- Fasting blood glucose \<5.6 mmol/L
Exclusion
- Smoking
- Allergic/intolerant to any of the test foods to be administered, or any of the following common food and ingredients: eggs, fish, milk, peanuts, and tree nuts, shellfish, soya, wheat, gluten, cereal, fruits, dairy products, meat, vegetable, sugar and sweetener, natural food colourings or flavourings, etc.
- Anyone with intentional food restrictions
- People with known glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency)
- Having metabolic or cardiovascular diseases (such as diabetes, hypertension, heart condition, etc.), Having any other diseases involving the small intestine or the colon (e.g., irritable bowel syndrome, inflammatory bowel disease, gastric reflux) or having any liver or kidney disorders or any family history of kidney stones
- Having medical conditions and/or taking medications known to affect glycaemia (glucocorticoids, thyroid hormones, thiazide diuretics)
- Taking any prescribed medication or dietary supplements which may interfere with the study measurements
- Individuals who have any major organ dysfunction (eg. cardiovascular, respiratory, hepatic, renal, gastrointestinal) that may influence taste, olfaction, appetite, digestion, metabolism, absorption or elimination of test foods, nutraceutical or drug
- Excessive alcohol consumption: consuming ≥ 6 alcoholic drinks per week
- Have known Chronic infection or known to suffer from or have previously suffered from or is a carrier of Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV)
- Have active Tuberculosis (TB) or currently receiving treatment for TB
- Individuals who partake in sports at the competitive and/or endurance levels
- A team member of the study or is an immediate family member (Immediate family defined as a spouse, parent, child, or sibling, whether biological or legally adopted
Key Trial Info
Start Date :
February 20 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 9 2020
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT04115592
Start Date
February 20 2019
End Date
March 9 2020
Last Update
August 20 2021
Active Locations (1)
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1
Clinical Nutrition Research Centre
Singapore, Singapore, 117599