Status:
COMPLETED
Blood Pressure After Endovascular Stroke Therapy-II
Lead Sponsor:
University of Cincinnati
Collaborating Sponsors:
National Institute of Neurological Disorders and Stroke (NINDS)
Vanderbilt University Medical Center
Conditions:
Acute Stroke
Endovascular Thrombectomy
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The purpose of this study is to assess the safety of lowering blood pressure in acute stroke patients that are successfully treated with a mechanical thrombectomy procedure. The investogators will eva...
Detailed Description
Several thousand patients suffer from an ischemic stroke caused by an occlusion of a large blood vessel supplying the brain. Endovascular mechanical thrombectomy (EVT) has revolutionized management of...
Eligibility Criteria
Inclusion
- Adult patients (≥18 years)
- Undergoing successful EVT (defined as modified Thrombolysis in Cerebral Ischemia Score, mTICI, ≥2b) for an occlusion in the anterior cerebral circulation large vessel (internal carotid artery and M1 or M2 segments of the middle cerebral artery).
- Intervention will be initiated only for those with a successful recanalization (modified Thrombolysis in Cerebral Ischemia Score ≥ 2b).
- Undergoing a baseline CT or MR perfusion study
- Those with unsuccessful recanalization (mTICI 0-2a) will be not intervened upon.
Exclusion
- Known heart failure with ejection fraction \<30%
- Presence of a left ventricular assist device
- Patients undergoing extracorporeal membrane oxygenation
- Pregnancy
- Enrollment in any other clinical trial
Key Trial Info
Start Date :
January 17 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 15 2022
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT04116112
Start Date
January 17 2020
End Date
December 15 2022
Last Update
October 12 2023
Active Locations (3)
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1
Hartford Healthcare
Hartford, Connecticut, United States, 06103
2
University of Cincinnati
Cincinnati, Ohio, United States, 45221
3
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37203