Status:
COMPLETED
Investigating Stress-related Mechanisms in the Laboratory and Real World in Individuals With Cannabis Use Disorder
Lead Sponsor:
Yale University
Collaborating Sponsors:
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Conditions:
Cannabis Use Disorder
Eligibility:
All Genders
18-50 years
Brief Summary
This research project proposes a novel approach to elucidate the biological adaptations associated with Cannabis Use Disorder and to assess whether such adaptations are predictive of higher drug cravi...
Detailed Description
The intent of this study is to recruit 25 treatment-seeking individuals with Cannabis Use Disorder (CUD) and 25 light users (\<1 joint/week) to complete three guided imagery conditions (stress, cannab...
Eligibility Criteria
Inclusion
- Cannabis using men and women who:
- 1\. Are fluent in English;
- 2\. Are using cannabis at levels to match either of the two groups:
- a) Light Users: i. Cannabis using levels of \< 1 joint/week ii. Has never met DSM-5 criteria for CUD or other substance use disorders. b) Individuals with Cannabis Use Disorder: i. Meets criteria for CUD based on the SCID (≤ 2 symptoms in past year); ii. Has a past-year cannabis use pattern of ≤3 times per week; iii.Do not meet criteria for any other substance use disorders other than mild Alcohol Use Disorder.
- 3\. Provide a negative breathalyzer for alcohol and only positive for cannabis use at all appointments;
- 4\. Can provide written informed consent.
Exclusion
- 1\. Meets current or past DSM-5 criteria for Axis I for major psychiatric disorders, other than depression or anxiety disorder;
- 2\. Meets criteria for a current Substance Use Disorder other than Cannabis or mild Alcohol Use Disorder;
- 3\. Has any significant current medical conditions requiring medication, including neurological, renal, thyroid, cardiovascular, liver, endocrine, or immune conditions;
- 4\. Reports current use of medications/drugs that interfere with HPA axis response,
- 5\. Are women who are pregnant or lactating, are peri-/post-menopausal, or those with hysterectomies;
- 6\. Report current use of psychotropic drugs other than antidepressants.
Key Trial Info
Start Date :
February 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 1 2022
Estimated Enrollment :
39 Patients enrolled
Trial Details
Trial ID
NCT04116619
Start Date
February 1 2021
End Date
February 1 2022
Last Update
February 21 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Yale Stress Center
New Haven, Connecticut, United States, 06519