Status:
UNKNOWN
Whole Body Magnetic Resonance Imaging Study
Lead Sponsor:
Royal Marsden NHS Foundation Trust
Collaborating Sponsors:
National Institute for Health Research, United Kingdom
Institute of Cancer Research, United Kingdom
Conditions:
Advanced Prostate Cancer
Eligibility:
MALE
18+ years
Brief Summary
In prostate cancer bone is the most common site for cancer spread, causing pain, fractures, nerve compression and death. New therapies are available for treating bone disease from cancer and this mea...
Detailed Description
In patients with prostate cancer the current methods to assess treatment response of bone disease such as computer tomography (CT) and bone scan (BS)are unreliable, insensitive to bone disease and hav...
Eligibility Criteria
Inclusion
- Written informed consent
- Age ≥18 years
- Patients with APC with predominantly bone disease confirmed by bone scan (within 6 weeks) or CT (within 6 weeks), of starting treatment (Cycle 1 Day 1). Patients with local recurrence and bone metastases with an associated soft tissue component, will be allowed into the trial. Pelvic lymphadenopathy \<1.5cm in short axis is not an exclusion.
- Systemic therapy indicated for disease progression, as clinically indicated.
Exclusion
- Patient is claustrophobic.
- Contraindications to MRI examination (e.g. cardiac pacemakers, cochlear implants).
- Measurable soft tissue or lymph node metastases or any metastatic disease outside the bone that is RECIST measurable will be an exclusion (unless it is pelvic nodal disease \<1.5cm in short axis). Bone metastases with associated soft tissue components will also not be an exclusion.
Key Trial Info
Start Date :
October 9 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2021
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT04117594
Start Date
October 9 2019
End Date
June 1 2021
Last Update
May 19 2021
Active Locations (1)
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1
The Royal Marsden NHS Foundation Trust
Sutton, Surrey, United Kingdom, SM2 5PT