Status:
RECRUITING
Central Sleep Apnea : Physiologic Mechanisms to Inform Treatment
Lead Sponsor:
VA Office of Research and Development
Conditions:
Sleep Disordered Breathing
Able Bodied
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Central sleep apnea (CSA) is common in patients with heart failure and those using opioid analgesics. Unfortunately, effective treatment of central apnea remains elusive, pressure therapy given the mo...
Detailed Description
All research activites are on hold due to COVID-19. We updated enrollment start date and we will update primary completion date and study completion date later. This project is focused on identifying...
Eligibility Criteria
Inclusion
- Men and women Veterans with central sleep apnea, defined as Apnea Hypopnea Index (AHI)\>15/hour with CAHI\>5/hour, will be included in the experiments
Exclusion
- less than 18 years old
- pregnant or breastfeeding female
- have severe respiratory disease that require to be on oxygen
- recent health event that may affect the ability to participate in the study,
- Body Mass Index (BMI) is \>40 kg/m2
- significant insomnia
- mental instability
- recent health event that may affect sleep
- if at any time the principal investigator (PI) identifies that a certain drug is not suitable, or are unable to use the device that is used to treat sleep apnea, will be not be allowed to participate in the study
Key Trial Info
Start Date :
January 7 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT04118387
Start Date
January 7 2021
End Date
December 31 2026
Last Update
April 10 2025
Active Locations (1)
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1
John D. Dingell VA Medical Center, Detroit, MI
Detroit, Michigan, United States, 48201-1916