Status:
ACTIVE_NOT_RECRUITING
Progressive Abduction Loading Therapy
Lead Sponsor:
Northwestern University
Collaborating Sponsors:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Shirley Ryan AbilityLab
Conditions:
Stroke, Acute
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
This study attempts to minimize the development of a common movement impairment following stroke known as "flexion synergy" that makes it extremely difficult to reach outward with the arm. Participant...
Detailed Description
Eighty-six individuals with acute (admission to in-patient rehabilitation) severe hemiparetic stroke (Chedoke McMaster Stroke Assessment arm score of Stage 2 or 3 out of 7) will participate in this st...
Eligibility Criteria
Inclusion
- Hemiparesis confined to one side, (CMSA Stage 2 or 3 out of 7)
- Stroke impacting parenchyma of the middle cerebral artery distribution
- Within 90 days post-stroke
- 18 to 85 years old
- No or Mild-to-moderate Aphasia (NIHSS #9 Best Language. = 0 or 1- Describe picture; No or Mild-to-moderate Aphasia)
- No or Mild extinction and inattention (NIHSS 11 Extinction and Inattention. = 0 or 1- No abnormality or Inattention to one modality.)
- Ability to perform a 3-step motor command with the unaffected arm
- Capacity to provide informed consent
Exclusion
- Premorbid and persistent disability or motor impairment of the upper extremities
- Brainstem and/or cerebellar lesion
- Comorbidity medically contraindicating motor assessments
- Any other chronic neurological condition
- Pain or hypersensitivity limiting motor assessments
- Limb edema limiting study motor assessments
Key Trial Info
Start Date :
August 27 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 31 2026
Estimated Enrollment :
86 Patients enrolled
Trial Details
Trial ID
NCT04118998
Start Date
August 27 2021
End Date
August 31 2026
Last Update
October 8 2025
Active Locations (3)
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1
Department of Physical Therapy and Human Movement Sciences
Chicago, Illinois, United States, 60611
2
Shirley Ryan AbilityLab
Chicago, Illinois, United States, 60611
3
Northwestern Medicine Marianjoy Rehabilitation Hospital
Wheaton, Illinois, United States, 60187