Status:
COMPLETED
A Multicenter Prospective Study of Application of Platelet Mapping in Acute-on-chronic-liver Failure in China
Lead Sponsor:
Nanfang Hospital, Southern Medical University
Collaborating Sponsors:
Southwest Hospital, China
The First Hospital of Jilin University
Conditions:
Thrombelastography
Acute on Chronic Liver Failure
Eligibility:
All Genders
18-80 years
Brief Summary
Ineffective hemostasis or a paradoxical prothrombotic state of Acute-on-chronic liver disease (ACLF) has been well established. Thrombelastography measures the dynamics of thrombin production and prov...
Eligibility Criteria
Inclusion
- INR≥1.5 and total bilirubin≥85μmol/L
Exclusion
- INR≤1.5 or total bilirubin≤85μmol/L;
- those who had hepatocellular carcinoma or other types of malignancies;
- obstructive biliary diseases or other disease lead to bilirubin evaluation;
- those who had acute hemorrhage one week before admission
- those who received platelet, cryo transfusion or plasmapheresis one week before admission
- pregnancy and breastfeeding
- those who received liver transplantation or kidney transplantation;
- combine with other disease lead to organ failure including heart failure (NYHA IV),respiratory failure（PaO2\<60mmHg),renal insufficiency(CKD 5) and conscious disturbance (GCS\<8)
- readmission;
- death within 24 hours.
Key Trial Info
Start Date :
August 16 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 4 2019
Estimated Enrollment :
486 Patients enrolled
Trial Details
Trial ID
NCT04119973
Start Date
August 16 2018
End Date
November 4 2019
Last Update
January 9 2020
Active Locations (1)
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1
Hepatology Unit, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University
Guangzhou, Guangdong, China, 510515