Status:

ACTIVE_NOT_RECRUITING

Estimating Setup Uncertainty in Pediatric Proton Therapy Using Volumetric Images

Lead Sponsor:

St. Jude Children's Research Hospital

Conditions:

Pediatric Cancer

Eligibility:

All Genders

Brief Summary

This research study establishes a repository for imaging data generated during image-guided proton therapy for various pediatric cancers. The data facilitate the estimation of patient positioning unce...

Detailed Description

Image guidance data collected in this study include daily volumetric pre-treatment CBCT for image guidance, post-correction CBCT, weekly post-treatment CBCT, and 2D orthogonal radiographs. Setup uncer...

Eligibility Criteria

Inclusion

  • Patient will receive proton therapy of ≥5 daily fractions.
  • Research participant or legal guardian/representative gives written informed consent.

Exclusion

  • Unwillingness of research participant or legal guardian/representative to give written informed consent.
  • If patients previously enrolled in this study and completed protocol-specified imaging scans but return for re-irradiation, they will not be eligible to participate again.

Key Trial Info

Start Date :

January 28 2020

Trial Type :

OBSERVATIONAL

Allocation :

ACTUAL

End Date :

October 31 2027

Estimated Enrollment :

367 Patients enrolled

Trial Details

Trial ID

NCT04125095

Start Date

January 28 2020

End Date

October 31 2027

Last Update

December 5 2025

Active Locations (1)

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St. Jude Children's Research Hospital

Memphis, Tennessee, United States, 38105