Status:
RECRUITING
Breathing-Maneuver-Induced Myocardial Oxygenation Reserve Validated by FFR (B-MORE)
Lead Sponsor:
McGill University Health Centre/Research Institute of the McGill University Health Centre
Conditions:
Coronary Artery Stenosis
Eligibility:
All Genders
18+ years
Brief Summary
The study aims to determine a diagnostic marker for regionally impaired myocardial oxygenation response in patients with suspected coronary artery stenosis.
Detailed Description
This observational applied research international study aims to assess the validity of breathing maneuvers as a vasoactive maneuver and Oxygenation-Sensitive Cardiac Magnetic Resonance Imaging (OS-CMR...
Eligibility Criteria
Inclusion
- Healthy Participants
- Age: \> 40y
- No known current or pre-existing significant medical problems that would affect the cardiovascular or respiratory system.
- CAD Patients
- Age \> 18 y
- Indication for invasive coronary angiography based on symptoms and a test positive for inducible coronary ischemia, or previous coronary angiography.
Exclusion
- ALL participants:
- General MRI contraindications: Pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, knowledge or suspicion of pregnancy.
- Consumption of caffeine (coffee, tea, cocoa, chocolate, "energy drink") during the 12 hours prior to the exam.
- Regular nicotine consumption during the last 6 months.
- Patients only
- Vasoactive medication (e.g. nitro) during the 12 hours prior to the exam Contraindications to adenosine (2nd or 3rd A-V block, sinus node disease, asthma, bronchoconstrictive diseases).
- Acute Coronary Syndrome (ACS), or previous Coronary Artery Bypass Surgery
- Previous myocardial infarction within 1 month
- Clinically unstable condition
- Significant or uncontrolled arrhythmia
Key Trial Info
Start Date :
July 4 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2024
Estimated Enrollment :
350 Patients enrolled
Trial Details
Trial ID
NCT04126148
Start Date
July 4 2019
End Date
December 1 2024
Last Update
October 24 2024
Active Locations (1)
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1
McGill University Health Center
Montreal, Quebec, Canada, H4A 3J1