Status:
UNKNOWN
Expression of Trefoil Factors and Adrenomedullin in Subjects With Chronic Periodontitis and Coronary Heart Disease
Lead Sponsor:
Meenakshi Ammal Dental College and Hospital
Conditions:
Coronary Heart Disease
Periodontal Diseases
Eligibility:
All Genders
30-65 years
Brief Summary
To assess the demographic variables, periodontal parameters and to determine the expression of Trefoil factors 2 and 3 and Adrenomedullin in unstimulated saliva samples of periodontally healthy subjec...
Detailed Description
A total of 75 subjects will be recruited for the study based on the power of the study. The selected subjects will be divided into 3 groups based on inclusion and exclusion criteria. GROUP I:25Gener...
Eligibility Criteria
Inclusion
- Patients willing to participate in the study.
- Patients within the age group of 30-65 years.
- Patients should have ≥ 20 remaining natural teeth.
- For Group I
- • Systemically healthy, Generalized chronic periodontitis subjects with 30% or more sites with clinical attachment loss (CAL) ≥ 2mm, radiographic evidence of alveolar crestal bone loss ≥ 2mm from the cemento-enamel junction.
- For Group II
- • Generalized chronic periodontitis subjects with 30% or more sites with clinical attachment loss (CAL) ≥ 2mm, radiographic evidence of alveolar crestal bone loss ≥ 2mm from the cemento-enamel junction along with coronary heart disease.
- For Group III • Periodontally healthy subjects with Probing pocket depth (PD) less than 4mm, bleeding on probing (BOP) at ≤15% of tooth sites, no periodontal treatment (Scaling and root planing or periodontal surgery) within the previous 6 months and without evident clinical signs of gingival inflammation along with the presence of coronary heart disease.
Exclusion
- Subjects with systemic conditions such as type I and type II diabetes mellitus, respiratory diseases, renal disease, liver disease, rheumatoid arthritis, allergy, advanced malignancies and HIV infection will be excluded from the present investigation.
- For Group I, subjects on drugs such as corticosteroids, antibiotics, within 6 months of investigation will be excluded.
- Current smokers and individuals who quit smoking less than 6 months.
- Patients who have undergone periodontal therapy within the previous 6 months.
- Pregnant women (pregnancy may alter the oral flora)
Key Trial Info
Start Date :
October 14 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 20 2021
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT04127474
Start Date
October 14 2019
End Date
November 20 2021
Last Update
September 2 2020
Active Locations (1)
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1
Meenakshi Ammal Dental College
Chennai, Tamil Nadu, India, 600095