Status:
NOT_YET_RECRUITING
Efficacy of Postoperative Radiotherapy for Atypical Meningioma Without Venous Sinus Invasion After Gross-total Resection
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang University
Collaborating Sponsors:
Sir Run Run Shaw Hospital
Zhejiang Provincial People's Hospital
Conditions:
Meningioma Atypical
Radiotherapy
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Postoperative adjuvant radiotherapy is a key component of comprehensive treatment of meningioma. However, for atypical meningioma after total resection, there is still a huge controversy in patients w...
Detailed Description
The study aims to enroll a total of 140 participants. Subjects would be enrolled with the following information: name, age, gender, contact, KPS score, preoperative ASA score, current ECOG score, tumo...
Eligibility Criteria
Inclusion
- Patients who underwent gross total resection at each center and were diagnosed as atypical meningioma (WHO class II) according to the WHO 2016 diagnostic criteria.
- Gross total resection was defined as modified Simpson 1-3 and confirmed by postoperative magnetic resonance imaging.
Exclusion
- age less than 18 years old or older than 70 years
- meningioma recurrence
- patients had previous radiotherapy
- multiple meningioma
- optic nerve sheath meningioma or other extracranial meningioma
- tumor involving venous sinus
- ECOG score ≥ 2 points
- preoperative ASA grade ≥ 3
- previous or current malignant tumors
- pregnant or lactating women
- Patients with Gd-DTPA allergies, spatial claustrophobia or pacemaker implantation that can not be conducted constract-enhanced head magnetic resonance examination
- patients who were unable to obtain informed consent or refused to participate in the study.
Key Trial Info
Start Date :
January 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2033
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT04127760
Start Date
January 1 2020
End Date
January 1 2033
Last Update
October 16 2019
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