Status:
UNKNOWN
Medical Imaging of Cachexia
Lead Sponsor:
Olivia Newton-John Cancer Research Institute
Collaborating Sponsors:
La Trobe University
Austin Health
Conditions:
Cancer Cachexia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This is a pilot trial using 18F-FDG PET and DXA scans to determine whether these investigations are objective tools to assess cachexia.
Detailed Description
This pilot study will establish the differences in BAT uptake of 18F-FDG in cachectic and non-cachectic cancer patients using PET imaging. Patients willbe assessed for sarcopenia using a dual energy ...
Eligibility Criteria
Inclusion
- Patients with malignant disease;
- ECOG Performance score of 0-2;
- Age ≥ 18 years;
- Life expectancy of \>4 months at screening;
- Cachexia patient group only: Fulfils diagnostic criteria for cachexia: unintentional weight loss more than 5% over the previous 6 months, or more than 2% in individuals with a decreased body-mass index of \<20kg/m2, or skeletal muscle wasting (sarcopenia).
Exclusion
- Patients with uncontrolled Diabetes Mellitus;
- Psychological unstable persons presumed unfit to perform the investigations;
- Persons unable to lie or sit still for 1-2 hours;
- Pregnant patients;
- Patients who received high doses of radiotherapeutic radiation of the neck and/or upper chest in their medical history limiting nutritional intake;
- Patients who are receiving any chemotherapeutic agents which is limiting nutritional intake;
- Persons that received cervical or thoracic sympathectomy or have a nerve dysfunction which is likely to influence sympathetic nerves;
- The use of medication that influences the sympathetic nerve system: ß-blockers, α-blockers, central anti-hypertensives, certain anti-depression drugs (MAO inhibitors, tricyclic antidepressives), reserpine, cocaine, calcium channel blockers, labetalol, and certain tranquillizers (fenothiazines).
Key Trial Info
Start Date :
March 28 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 28 2023
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04127981
Start Date
March 28 2019
End Date
December 28 2023
Last Update
March 23 2023
Active Locations (1)
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1
Austin Health
Heidelberg, Victoria, Australia, 3078