Status:
COMPLETED
Neurobiological Responses in Alcoholism and Early Trauma
Lead Sponsor:
Yale University
Collaborating Sponsors:
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Conditions:
Alcohol Use Disorder
Early Trauma Complications
Eligibility:
All Genders
21-55 years
Phase:
NA
Brief Summary
Alcohol use disorder (AUD) accompanied by early trauma presents clinical challenges, including elevated rates of comorbid emotional symptoms and relapse. To better understand this co-occurring conditi...
Detailed Description
The study recruited four demographically matched groups (age, sex ratio): individuals with AUD with and without a history of early trauma, and moderate drinkers with and without early trauma. Study pr...
Eligibility Criteria
Inclusion
- AUD inclusion Criteria:
- Alcohol use disorder
- Either low or high early trauma (based on the Childhood Trauma Questionnaire)
- Body mass index (BMI) up to 35 (due to weight limitations of the MRI scanner)
- AUD exclusion Criteria:
- Current or past substance use disorder other than alcohol; excluding caffeine and nicotine
- Psychiatric disorders except for mood and anxiety disorders
- Any significant current medical conditions
- Women who are peri- and post- menopausal, pregnant or lactating
- MRI specific exclusion criteria (e.g., claustrophobia, implanted metal in the body)
Exclusion
Key Trial Info
Start Date :
October 3 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 8 2023
Estimated Enrollment :
148 Patients enrolled
Trial Details
Trial ID
NCT04128228
Start Date
October 3 2019
End Date
September 8 2023
Last Update
November 14 2024
Active Locations (1)
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1
Yale University
New Haven, Connecticut, United States, 06492