Status:
COMPLETED
MechSens - Dose-response Relationship of in Vivo Ambulatory Load and Mechanosensitive Cartilage Biomarkers
Lead Sponsor:
University Hospital, Basel, Switzerland
Collaborating Sponsors:
Swiss National Science Foundation
Conditions:
Articular Cartilage Degeneration
Eligibility:
All Genders
20-60 years
Phase:
NA
Brief Summary
This study is to investigate the effects of age, tissue status and the presence of inflammation on the in vivo dose-response relationship of ambulatory load and mechanosensitive blood markers of artic...
Detailed Description
Articular cartilage is an avascular and aneural tissue that facilitates joint motion with minimal friction. Osteoarthritis (OA) is a joint disease that affects the whole joint resulting in severe arti...
Eligibility Criteria
Inclusion
- Inclusion Criteria for group 1 and 3:
- Being physically active (\>2hours/week)
- No previous known knee injury:
- Inclusion Criteria for group 2 and 4:
- Being physically active (\>2hours/week)
- ACL rupture between 2 to 10 years prior to the study
- Exclusion Criteria:
- Inability to provide informed consent
- Age \< 20 years (before maturation) or age \> 60 years
- Advanced general sarcopenia (degenerative loss of muscle mass in aging) and high likelihood of osteoarthritic changes
- Body mass index (BMI) \> 35 kg/m2:
- Excessive skin movement that influences the gait analysis
- Inability to walk for 30 minutes
- Contraindications for a knee MRI
- Active rheumatic disorder
- Prior neuromuscular impairment (e.g. stroke)
- Conditions other than knee injury that could cause abnormal patterns of locomotion
- Prior hip, knee, and ankle prosthesis
- Osteotomy of the lower extremities - Prior spine surgery
- Other major medical problems
- Pregnancy
- Investigators and their immediate families are not permitted to be subjects
- Persons who have previously completed or withdrawn from this study
- Patients currently enrolled in another experimental (interventional) protocol
Exclusion
Key Trial Info
Start Date :
January 8 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 7 2024
Estimated Enrollment :
87 Patients enrolled
Trial Details
Trial ID
NCT04128566
Start Date
January 8 2020
End Date
July 7 2024
Last Update
December 27 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Orthopaedics and Traumatology, University Hospital Basel
Basel, Switzerland, 4031