Status:
COMPLETED
Evaluating the Combined Intervention of Nutritional Supplementation (Remune) and Exercise in Patients With Cancer Cachexia
Lead Sponsor:
University of Rochester
Collaborating Sponsors:
Smartfish AS
Conditions:
Cachexia; Cancer
Weight Loss
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
The main purpose of this research study is to determine if the use of a nutritional supplement and exercise improve or worsen cachexia.
Detailed Description
In this study the investigator would like to better understand how cachexia may improve or worsen, and how exercise and nutritional supplements may impact this process. The investigator would like to ...
Eligibility Criteria
Inclusion
- Be over the age of 18 years and have a primary diagnosis of colorectal, esophageal, gastric, pancreatic, biliary tract cancer (includes cholangiocarcinoma, gallbladder cancer, and ampullary cancer), or Non-small cell lung cancer (NSCLC) with plans to initiate systemic chemotherapy, targeted therapy or immunotherapy within the next 4 weeks after enrollment.
- Have been diagnosed as having an unresectable cancer with no plans for surgical intervention during the active study period (12 weeks).
- Have an ECOG performance score of 0 or 1.
- Have a life expectancy of \>3 months as determined by their primary oncologist.
- Have experienced at least 2% weight loss of the patient's reported previous body weight over the 6 months prior to enrollment.
- Have permission from primary oncologist to engage in low to moderate intensity exercise regimen.
- Be able to read English (since the assessment materials are in printed format).
- Be able to give written informed consent.
Exclusion
- Have any of the following limitations: unable to perform low-to-moderate intensity exercise regimen.
- Have had major surgery (excluding diagnostic procedures like laparoscopy, EGD/EUS, esophageal stent placement) in the past 4 weeks.
- Be experiencing dysphagia that requires enteral or parenteral feeding for nutrition.
- Be enrolled on hospice at time of consent.
- Be engaged in an active exercise routine by being identified as in the Active or Maintenance Stage of exercise behavior as assessed by the 1-item Exercise Stages of Change Short Form (67).
- Use of nutritional supplements containing EPA/DHA within 2 weeks prior to screening
- Current Use of Vitamin D supplementation or St. John's wort that can influence efficacy and safety parameters. Chronic treatment (\>12 weeks prior to screening) with multivitamin tablets is allowed (vitamin tablets must not contain more vitamin D than 150% of the recommended dietary allowance \[RDA\]).
- Known hypersensitivity or allergy to any of the study products. Specifically, patients allergic to milk, fish or shellfish will be excluded.
- Have AST/ALT \>3x upper limit of normal (ULN) or \>5xULN in those with liver metastases, Serum creatinine \>2x ULN, Absolute Neutrophil Count \<1,500/uL, Hemoglobin \<9, Platelet count \<75,000/uL at the time of baseline blood draw or any other Blood chemistry or hematology lab abnormalities that would exclude them from being able to receive standard chemotherapy or interventional clinical trial.
- Have uncontrolled Diabetes Mellitus as determined by primary oncologist or PI.
Key Trial Info
Start Date :
April 24 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2022
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT04131426
Start Date
April 24 2020
End Date
April 1 2022
Last Update
August 15 2023
Active Locations (1)
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1
University of Rochester
Rochester, New York, United States, 14642