Status:
COMPLETED
Mechanisms Underlying Local and Systemic Effects of Massage
Lead Sponsor:
Esther Dupont-Versteegden
Collaborating Sponsors:
University of Oklahoma
National Center for Complementary and Integrative Health (NCCIH)
Conditions:
Muscle Atrophy
Eligibility:
All Genders
18-30 years
Phase:
NA
Brief Summary
The purpose of this study is to determine whether massage can attenuate the loss of muscle mass in humans after a short period of disuse.
Detailed Description
The loss of skeletal muscle mass is a common symptom associated with diseases such as cancer, AIDS, diabetes, and congestive heart failure, and with aging. Muscle atrophy is associated with poor disea...
Eligibility Criteria
Inclusion
- Men and women 18-30 years of age.
- All races and ethnic backgrounds.
- Non-smoker and generally healthy.
Exclusion
- Have a current lower extremity musculoskeletal injury or compromised musculoskeletal function that would not allow the safe use of crutches or a brace.
- Previous lower extremity surgeries or injury.
- Activities of daily living require long periods of standing or driving a manual transmission car.
- Body mass index (BMI) under 27.
- Evidence or signs and symptoms of metabolic syndrome or disorder (diagnosis of diabetes or insulin resistance, elevated BP, high fasting blood sugar, abnormal cholesterol or triglyceride levels).
- Thyroid disorder.
- Acute or chronic infections.
- Use of systemic steroids, anabolic steroids, or growth hormone.
- Chronic aspirin or NSAID use (unless it can be safely stopped prior to the biopsies), and any other use of an anticoagulant (e.g., Coumadin) or history of bleeding including history of hypo- or hyper-coagulation disorders.
- Lidocaine allergy (1% lidocaine is the local anesthetic used during the muscle biopsy procedure).
- Any other condition or events considered exclusionary by the PI and/or physician, such as non-compliance.
- Pregnancy.
Key Trial Info
Start Date :
August 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2023
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT04131712
Start Date
August 1 2020
End Date
June 1 2023
Last Update
May 21 2024
Active Locations (1)
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1
University of Kentucky
Lexington, Kentucky, United States, 40536