Status:
WITHDRAWN
Curcumin and Exercise in Chronic Kidney Disease
Lead Sponsor:
University of Iowa
Conditions:
Chronic Kidney Diseases
Blood Pressure
Eligibility:
All Genders
45-80 years
Phase:
PHASE2
Brief Summary
Chronic kidney disease (CKD) is associated with a pro-oxidative and pro-inflammatory state, and this is thought to contribute to a decrease in vascular function leading to greater cardiovascular disea...
Detailed Description
Active muscles require an optimal amount of local blood flow to meet the functional and metabolic demand of the exercising muscle. It is well known that maximal aerobic work capacity and exercise tole...
Eligibility Criteria
Inclusion
- Inclusion Criteria for CKD subjects:
- Age 45-80 years old CKD stage III and IV (estimated glomerular filtration rate: 15-60 mL/min/1.73m2) BMI \<40 kg/m2-1 Able to give informed consent
- Exclusion Criteria for CKD subjects will include answering yes to the following questions:
- Active participation in another study?
- Dialysis?
- End stage renal disease or kidney failure?
- Kidney transplant?
- Sever liver disease or transplant?
- Diabetes?
- Angina (i.e., chest discomfort/pain/pressure upon exertion)
- Severe congestive heart failure?
- Pacemaker/defibrillator?
- Heart arrhythmia (i.e. Atrial fibrillation/flutter)?
- Pregnant, breastfeeding, or unwilling to use adequate birth control?
- Active infection or antibiotic therapy?
- Immunosuppressive therapy within the last 3 months?
- History of stroke?
- Have you had a heart attack in the last 3 months?
- Have you taken curcumin in last 3 months?
- Current use of Hormone Replacement Therapy (if female)?
- Current smoker?
- Anemic (Hemoglobin count \<9)?
- Inclusion Criteria for healthy middle-age and older subjects:
- Age 45-80 years old BMI \<40 kg/m2 1 Able to give informed consent
- Exclusion Criteria for health older subjects will include answering yes to the following questions:
- Chronic kidney disease?
- Hypertension?
- Asthma?
- Heart disease?
- Clinical depression?
- Autonomic disorders?
- Sleep apnea?
- Sever liver disease or transplant?
- Diabetes?
- Heart attack?
- Angina (i.e., chest discomfort/pain/pressure upon exertion)
- Severe systolic or congestive heart failure?
- Heart angioplasty/stent or bypass surgery?
- Heart valve surgery/replacement or valve disease?
- Pacemaker/defibrillator?
- Heart arrhythmia (i.e. Atrial fibrillation/flutter)?
- Pregnant, breastfeeding, or unwilling to use adequate birth control?
- Active infection or antibiotic therapy?
- Immunosuppressive therapy within the last 3 months?
- Have you taken curcumin in last 3 months?
- Current use of Hormone Replacement Therapy (if female)?
- Current smoker?
- Anemic (Hemoglobin count \<9)?
Exclusion
Key Trial Info
Start Date :
November 15 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2021
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04132648
Start Date
November 15 2020
End Date
November 1 2021
Last Update
February 21 2023
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