Status:
TERMINATED
TIME ASPIRIN: Chronotherapy With Aspirin for Reduction of Cardiovascular Disease
Lead Sponsor:
Leiden University Medical Center
Collaborating Sponsors:
ZonMw: The Netherlands Organisation for Health Research and Development
Conditions:
Cardiovascular Diseases
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study will be a comparative effectiveness research to determine the difference in major adverse cardiovascular events between the group with aspirin after awakening and placebo before bedtime and...
Detailed Description
Aspirin is the cornerstone of preventive cardiovascular disease (CVD) treatment and bedtime intake of aspirin (chronotherapy) has been shown to reduce morning activity of platelets. It has been shown ...
Eligibility Criteria
Inclusion
- Use of low-dose aspirin (acetylsalicylic acid 80mg \[brand name: acetylsalicylic acid cardio TEVA\]\~)
- Patients using aspirin from an MDD ('Baxter')
- Capacity to give informed consent (IC)
Exclusion
- Pregnancy
- Mental or physical disability to fulfil study requirements
- Insufficient knowledge of the Dutch language
- Patients currently participating in another (clinical) trial or study
Key Trial Info
Start Date :
October 7 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 31 2022
Estimated Enrollment :
328 Patients enrolled
Trial Details
Trial ID
NCT04132791
Start Date
October 7 2019
End Date
March 31 2022
Last Update
June 24 2022
Active Locations (1)
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1
Leiden University Medical Center
Leiden, South Holland, Netherlands, 2333 ZA