Status:
RECRUITING
ICONIC: Improving Outcomes Through Collaboration in OsteosarComa
Lead Sponsor:
University College, London
Collaborating Sponsors:
Bone Cancer Research Trust
Conditions:
Osteosarcoma
Eligibility:
All Genders
Brief Summary
There has been little improvement in outcome for patients with osteosarcoma (OS) over the last 20 years. There have been only a few clinical trials of new treatments and no major new therapies introdu...
Detailed Description
Osteosarcoma is the most common bone sarcoma, accounting for approximately 30% of all bone sarcoma diagnoses. In England, it accounts for approximately 130 cases per year across all ages. Generally o...
Eligibility Criteria
Inclusion
- New histological diagnosis of osteosarcoma or in the absence of osteoid seen on biopsy, pathology and imaging supportive of a diagnosis of osteosarcoma. (It is well recognised that some patients may present with features suggestive of osteosarcoma (under 40 years, radiological abnormality compatible) but in whom no osteoid is detected in needle biopsy. Although categorised as spindle cell tumour of bone, such patients are usually treated in an identical approach to osteosarcoma. A definite diagnosis of osteosarcoma is then often possible after surgery when the entire resection specimen is available.)
- Written informed consent of patient and/or parent/legal guardian.
Exclusion
- • Diagnosis more than four months prior to registration.
Key Trial Info
Start Date :
October 25 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 31 2027
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT04132895
Start Date
October 25 2019
End Date
January 31 2027
Last Update
August 2 2024
Active Locations (22)
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1
University College Hospitals London NHS Foundation Trust
London, Greater London, United Kingdom, NW1 2BU
2
NHS Grampian Health Board
Aberdeen, United Kingdom
3
Birmingham Women's and Childrens NHS Foundation Trust
Birmingham, United Kingdom
4
The Royal Orthopaedic Hospital NHS Foundation Trust
Birmingham, United Kingdom