Status:
UNKNOWN
The Effect of Viscous Dietary Fibers on LDL-cholesterol
Lead Sponsor:
Unity Health Toronto
Conditions:
Cardiovascular Risk Factor
Hypercholesterolemia
Eligibility:
All Genders
18+ years
Brief Summary
This systematic review and meta-analysis is aimed to assess the effect of commonly consumed viscous fibers on blood lipids including LDL-C, non-HDL-C, and ApoB.
Detailed Description
Medline, Embase, CINAHL, and the Cochrane Central databases were searched through May 13, 2019. Three independent reviews extracted data and assessed risk of bias. Randomized controlled trials that as...
Eligibility Criteria
Inclusion
- Must be a randomized controlled clinical trial with either a parallel or cross-over design
- have a treatment period of at least 3 weeks
- Hypercholesterolemic or normocholesterolemic adults, overweight and obese individuals or individuals with diabetes were all acceptable
- Sources from β-glucan oats, β-glucan barley, konjac, psyllium, guar gum, and pectin were accepted
- The amount of soluble fiber must be reported or measured or must be computable.
- Must be appropriately controlled.
- Must measure one of LDL-C, non-HDL-C or ApoB. These lipid measures can be either primary or secondary outcomes.
- Enough information must be provided to calculate the magnitude of effect, i.e. end of treatment measures and/or change from baseline measures
Exclusion
- If the study was insufficiently controlled, i.e. the control was another soluble fiber
- If the soluble fiber was a combination supplement or in whole food sources where the amount of soluble fiber could not be isolated
- If the outcome measures did not include LDL-C, non-HDL-C or ApoB
- If the treatment period was less than 3 weeks
- If the study was from a non-adult population
- If the study provided insufficient information to calculate a magnitude of effect
- Secondary information such as reviews, editorials, commentaries, were excluded
- If the dose was less than 0.4g/day
Key Trial Info
Start Date :
September 17 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2020
Estimated Enrollment :
7845 Patients enrolled
Trial Details
Trial ID
NCT04133805
Start Date
September 17 2018
End Date
January 1 2020
Last Update
October 21 2019
Active Locations (1)
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1
Clinical Risk Factor and Modification Centre
Toronto, Ontario, Canada, M5C 2T2