Status:
COMPLETED
Methadone Induced Memory Retrieval-extinction Procedure in Heroin Addicts
Lead Sponsor:
National Institute on Drug Dependence, China
Conditions:
Heroin Dependence
Eligibility:
MALE
18-55 years
Phase:
NA
Brief Summary
The study assessed the efficacy of a methadone-induced memory retrieval-extinction procedure on heroin craving and relapse. Male participants aged 18-55 years old and prescribed MMT to treat heroin de...
Detailed Description
In the present study, we explored the effect retrieval-extinction procedure on heroin craving and relapse in heroin addicts using the methadone (a commonly used µ-opioid receptor agonist) instead of h...
Eligibility Criteria
Inclusion
- met the diagnostic criteria of heroin dependence according to DSM-IV
- were prescribed methadone maintenance treatment (MMT) and took it regularly
- no change in city of residence for at least 1 year
- had normal blood pressure and heart rate
- had negative urine morphine screening test
- primary-school level education
- provide signed consent
Exclusion
- other substance abuse(except nicotine)
- had a current or past history of Diagnostic and Statistical Manual of Mental Disorders, 4th Edition（DSM-IV) AxisⅠdisorders
- had clinically evident physical disorders
- neurological signs and/or history of neurological disease
- noncompliance with the procedure
Key Trial Info
Start Date :
November 20 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 20 2019
Estimated Enrollment :
87 Patients enrolled
Trial Details
Trial ID
NCT04133974
Start Date
November 20 2015
End Date
April 20 2019
Last Update
October 21 2019
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