Status:
UNKNOWN
Effects of tACS Combined With CCT for Patients With MCI
Lead Sponsor:
Shanghai Mental Health Center
Collaborating Sponsors:
Yangpu District Central Hospital Affiliated to Tongji University
Conditions:
Mild Cognitive Impairment
Eligibility:
All Genders
60-95 years
Phase:
NA
Brief Summary
This goal of this study is to explore the effects of transcranial alternating current stimulation(tACS) combined with computerized cognitive training(CCT) on improving cognition for patients with mild...
Detailed Description
tACS is a non-invasive brain stimulation technique that uses a low-intensity alternating current (1 to 2 mA) to apply a sinusoidal current to the scalp, directly interacting with the oscillating corti...
Eligibility Criteria
Inclusion
- (1)age ≥ 60 years old with memory impairment; (2) the memory test scores are lower 1.5 SD than the normal control; (3) in addition to memory impairment, other cognitive functions remain relatively intact or only slightly impaired; (4) normal daily living ability; (5) can not reach the diagnostic criteria for dementia, Clinical Dementia Rating (CDR) is 0.5
Exclusion
- (1) serious medical diseases such as hypertension, heart disease, severe liver disease, etc.; (2) central nervous system diseases such as cerebrovascular diseases, infectious encephalopathy, brain tumors, etc.; (3) severe depression, schizophrenia and patients who have taken psychotropic substances for a long time; (4) Alzheimer's disease and vascular dementia; (5) history of alcohol dependence and other psychoactive substance abuse; (6) patients with contraindications for magnetic resonance imaging; (7) cannot complete the cognitive function tests for various conditions
Key Trial Info
Start Date :
November 11 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2023
Estimated Enrollment :
195 Patients enrolled
Trial Details
Trial ID
NCT04135742
Start Date
November 11 2019
End Date
December 30 2023
Last Update
May 6 2022
Active Locations (2)
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1
Shanghai Mental Health Center
Shanghai, Shanghai Municipality, China, 200030
2
Yangpu District Central Hospital
Shanghai, China