Status:
COMPLETED
Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Fentanyl
Lead Sponsor:
University of Texas Southwestern Medical Center
Collaborating Sponsors:
United States Department of Defense
Conditions:
Healthy
Eligibility:
All Genders
18-45 years
Phase:
PHASE1
PHASE2
Brief Summary
The purpose of this project is to test how fentanyl, an analgesic currently employed in the pre-hospital setting by the US Army, alters the capacity to tolerate a hemorrhagic insult in humans.
Detailed Description
Pain management on the battlefield is critical for the wellbeing of the soldier. Given that a hemorrhagic injury on the battlefield is virtually always associated with pain, it is paramount that the s...
Eligibility Criteria
Inclusion
- Healthy
- Non-obese (body mass index less than 30 kg/m2)
- Body mass greater than or equal to 65 kg
Exclusion
- Subjects who have cardiac, respiratory, neurological and/or metabolic illnesses
- Any known history of renal or hepatic insufficiency/disease
- Pregnancy or breast feeding
- Current smokers, as well as individuals who regularly smoked within the past 3 years
- Positive urine drug screen
- Currently taking pain modifying medication(s)
Key Trial Info
Start Date :
June 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 18 2020
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT04136548
Start Date
June 1 2019
End Date
November 18 2020
Last Update
January 24 2022
Active Locations (1)
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1
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390