Status:
UNKNOWN
Methacholine, Long-acting M-cholinolytic and beta2-agonist on the Activity of Beta-receptors in Healthy Volunteers
Lead Sponsor:
Federal State Budgetary Institution, Pulmonology Scientific Research Institute
Collaborating Sponsors:
Moscow State University of Medicine and Dentistry
National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Conditions:
Health, Subjective
Hyperreactivity, Bronchial
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Interventional open-labeled study in parallel groups is aimed to evaluate changes of beta receptors in healthy volunteers under the influence of inhaled metacholine, long-acting anticholinergics and b...
Detailed Description
Long-acting beta2-agonists and anticholinergics are main drugs in therapy of chronic obstructive pulmonary disease . Beta-agonists exert their bronchodilatory effects via β2 adrenoceptors located on a...
Eligibility Criteria
Inclusion
- 1 Provision of signed and dated informed consent form 2. Healthy male or female, aged 18-60 years
Exclusion
- Participants unable to perform spirometry
- Exacerbation respiratory infection within the previous four weeks
- Hypersensitivity or allergy to formoterol, metacholine or tiotropium bromide
- Females who are currently pregnant and lactating
- major surgery in the last 6 months
- Refusal to participate
- Currently participating in another clinical study
Key Trial Info
Start Date :
April 24 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2020
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04137029
Start Date
April 24 2019
End Date
October 1 2020
Last Update
October 23 2019
Active Locations (1)
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1
Kirill Zykov
Moscow, Russia, 115682