Status:
COMPLETED
Metabolomics of Intraoperative Saline and Balanced Crystalloid Infusion
Lead Sponsor:
National Taiwan University Hospital
Conditions:
Metabolomics
Eligibility:
All Genders
40-65 years
Phase:
NA
Brief Summary
Different crystalloids, namely 0.9% saline and balanced crystalloid may result in different metabolomic profile among surgical patients. This study aims to investigate the serum and urine profiles bet...
Detailed Description
Intravenous fluid is mandatory for acute and critically ill patients as well as for surgical patients. Two crystalloid iv. solutions namely 0.9% saline and balanced crystalloid are the most commonly a...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- age between 40 and 65 year-old
- major lumbar spine surgery (spinal fusion、multiple levels or expected operation time\> 2 hr)
- Exclusion criteria:
- Preoperative organ dysfunction, such as impaired liver function, eg. AST or ALT \>100; liver cirrhosis \> Child B class; Impaired renal function, eGFR\< 60 ml/min/1.73 m2; cardiac dysfunction, such as heart failure \> NYHA class II, coronary arterial disease, chronic obstructive pulmonary disease
- Preoperative use of medications which interfere with liver, renal, glucose or electrolyte metabolism, such as insulin, statin or digoxin
- Pregnancy
Exclusion
Key Trial Info
Start Date :
March 25 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 3 2021
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT04137042
Start Date
March 25 2020
End Date
May 3 2021
Last Update
July 19 2022
Active Locations (1)
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1
National Taiwan University Hospital
Taipei, Taiwan